Table 1

By AKI

##                              Stratified by bin_aki48h
##                               0                 1                 p      test
##   n                              1097               185                      
##   val_age (mean (SD))           66.66 (8.47)      68.57 (8.28)     0.005     
##   cat_gender = Male (%)           865 (78.9)        145 (78.4)     0.961     
##   val_bmi (mean (SD))           29.89 (5.83)      31.07 (5.68)     0.011     
##   val_egfr (mean (SD))          78.01 (19.27)     65.02 (24.36)   <0.001     
##   bin_htn = 1 (%)                 275 (25.1)         56 (30.3)     0.160     
##   bin_diabetes = 1 (%)            209 (19.1)         45 (24.3)     0.118     
##   bin_mi = 1 (%)                  257 (23.4)         54 (29.2)     0.110     
##   bin_chf = 1 (%)                  31 ( 2.8)          6 ( 3.2)     0.939     
##   cat_ef (%)                                                      <0.001     
##      15-20%                         4 ( 0.4)          3 ( 1.6)               
##      20-25%                        13 ( 1.2)          1 ( 0.5)               
##      25-30%                        25 ( 2.3)          7 ( 3.8)               
##      30-35%                        25 ( 2.3)         11 ( 5.9)               
##      35-40%                        49 ( 4.5)          8 ( 4.3)               
##      40-45%                        58 ( 5.3)         21 (11.4)               
##      45-50%                        89 ( 8.1)         13 ( 7.0)               
##      50-55%                       128 (11.7)         18 ( 9.7)               
##      55-60%                       491 (44.8)         66 (35.7)               
##      60-65%                       163 (14.9)         24 (13.0)               
##      65-70%                        46 ( 4.2)          9 ( 4.9)               
##      70-75%                         6 ( 0.5)          4 ( 2.2)               
##   bin_iabp = 1 (%)                 21 ( 1.9)          8 ( 4.3)     0.076     
##   bin_stroke = 1 (%)               22 ( 2.0)          5 ( 2.7)     0.738     
##   bin_pvd = 1 (%)                  31 ( 2.8)          5 ( 2.7)     1.000     
##   bin_cld = 1 (%)                  22 ( 2.0)          4 ( 2.2)     1.000     
##   bin_betablocker = 1 (%)         868 (79.1)        155 (83.8)     0.174     
##   bin_acearb = 1 (%)              724 (66.0)        140 (75.7)     0.012     
##   bin_statin = 1 (%)              935 (85.2)        167 (90.3)     0.087     
##   val_creatlst (mean (SD))       1.04 (0.32)       1.33 (0.66)    <0.001     
##   bin_redo = 1 (%)                  2 ( 0.2)          0 ( 0.0)     1.000     
##   bin_emergent = 1 (%)             72 ( 6.6)         11 ( 5.9)     0.877     
##   bin_aki48h (mean (SD))         0.00 (0.00)       1.00 (0.00)    <0.001     
##   val_proctime (mean (SD))     345.80 (66.54)    368.54 (81.06)   <0.001     
##   val_crystalloid (mean (SD)) 6761.85 (2108.51) 6683.78 (1948.04)  0.638     
##   cat_rbc (%)                                                     <0.001     
##      >1                            74 ( 6.7)         31 (16.8)               
##      0                            946 (86.2)        124 (67.0)               
##      1                             77 ( 7.0)         30 (16.2)               
##   val_cpbtime (mean (SD))      102.72 (35.46)    114.44 (41.88)   <0.001     
##   val_ef (mean (SD))            54.17 (9.95)      52.14 (11.97)    0.013     
##   bin_ef40 = >40% (%)             981 (89.4)        155 (83.8)     0.035

By Tertiles of minutes in ranges

Time with CI < 2

## 33.33333% 66.66667% 
##         1        33
##                              Stratified by tertile
##                               t1                t2               
##   n                               428               427          
##   val_age (mean (SD))           65.33 (8.32)      66.35 (8.35)   
##   cat_gender = Male (%)           351 (82.0)        352 (82.4)   
##   val_bmi (mean (SD))           30.01 (5.64)      30.09 (5.65)   
##   val_egfr (mean (SD))          77.79 (21.41)     79.12 (19.90)  
##   bin_htn = 1 (%)                  91 (21.3)        117 (27.4)   
##   bin_diabetes = 1 (%)             75 (17.5)         90 (21.1)   
##   bin_mi = 1 (%)                  105 (24.5)         99 (23.2)   
##   bin_chf = 1 (%)                   7 ( 1.6)          7 ( 1.6)   
##   cat_ef (%)                                                     
##      15-20%                         3 ( 0.7)          2 ( 0.5)   
##      20-25%                         5 ( 1.2)          5 ( 1.2)   
##      25-30%                        10 ( 2.3)         10 ( 2.3)   
##      30-35%                        13 ( 3.0)          8 ( 1.9)   
##      35-40%                         9 ( 2.1)         29 ( 6.8)   
##      40-45%                        21 ( 4.9)         33 ( 7.7)   
##      45-50%                        34 ( 7.9)         27 ( 6.3)   
##      50-55%                        43 (10.0)         53 (12.4)   
##      55-60%                       204 (47.7)        183 (42.9)   
##      60-65%                        63 (14.7)         59 (13.8)   
##      65-70%                        20 ( 4.7)         14 ( 3.3)   
##      70-75%                         3 ( 0.7)          4 ( 0.9)   
##   bin_iabp = 1 (%)                  4 ( 0.9)          5 ( 1.2)   
##   bin_stroke = 1 (%)                4 ( 0.9)          9 ( 2.1)   
##   bin_pvd = 1 (%)                  12 ( 2.8)         11 ( 2.6)   
##   bin_cld = 1 (%)                   9 ( 2.1)         10 ( 2.3)   
##   bin_betablocker = 1 (%)         331 (77.3)        341 (79.9)   
##   bin_acearb = 1 (%)              284 (66.4)        287 (67.2)   
##   bin_statin = 1 (%)              371 (86.7)        361 (84.5)   
##   val_creatlst (mean (SD))       1.08 (0.44)       1.05 (0.38)   
##   bin_redo = 1 (%)                  0 ( 0.0)          1 ( 0.2)   
##   bin_emergent = 1 (%)             28 ( 6.5)         29 ( 6.8)   
##   bin_aki48h (mean (SD))         0.14 (0.35)       0.12 (0.32)   
##   val_proctime (mean (SD))     338.65 (62.02)    339.13 (64.41)  
##   val_crystalloid (mean (SD)) 6588.79 (2105.74) 6853.63 (2099.69)
##   cat_rbc (%)                                                    
##      >1                            26 ( 6.1)         28 ( 6.6)   
##      0                            367 (85.7)        372 (87.1)   
##      1                             35 ( 8.2)         27 ( 6.3)   
##   val_cpbtime (mean (SD))       98.90 (33.67)    103.01 (34.30)  
##   val_ef (mean (SD))            54.52 (10.12)     53.47 (10.18)  
##   bin_ef40 = >40% (%)             388 (90.7)        373 (87.4)   
##                              Stratified by tertile
##                               t3                p      test
##   n                               427                      
##   val_age (mean (SD))           69.15 (8.28)    <0.001     
##   cat_gender = Male (%)           307 (71.9)    <0.001     
##   val_bmi (mean (SD))           30.08 (6.18)     0.974     
##   val_egfr (mean (SD))          71.49 (19.64)   <0.001     
##   bin_htn = 1 (%)                 123 (28.8)     0.027     
##   bin_diabetes = 1 (%)             89 (20.8)     0.345     
##   bin_mi = 1 (%)                  107 (25.1)     0.805     
##   bin_chf = 1 (%)                  23 ( 5.4)     0.001     
##   cat_ef (%)                                     0.278     
##      15-20%                         2 ( 0.5)               
##      20-25%                         4 ( 0.9)               
##      25-30%                        12 ( 2.8)               
##      30-35%                        15 ( 3.5)               
##      35-40%                        19 ( 4.4)               
##      40-45%                        25 ( 5.9)               
##      45-50%                        41 ( 9.6)               
##      50-55%                        50 (11.7)               
##      55-60%                       170 (39.8)               
##      60-65%                        65 (15.2)               
##      65-70%                        21 ( 4.9)               
##      70-75%                         3 ( 0.7)               
##   bin_iabp = 1 (%)                 20 ( 4.7)    <0.001     
##   bin_stroke = 1 (%)               14 ( 3.3)     0.058     
##   bin_pvd = 1 (%)                  13 ( 3.0)     0.918     
##   bin_cld = 1 (%)                   7 ( 1.6)     0.760     
##   bin_betablocker = 1 (%)         351 (82.2)     0.208     
##   bin_acearb = 1 (%)              293 (68.6)     0.776     
##   bin_statin = 1 (%)              370 (86.7)     0.587     
##   val_creatlst (mean (SD))       1.12 (0.39)     0.056     
##   bin_redo = 1 (%)                  1 ( 0.2)     0.605     
##   bin_emergent = 1 (%)             26 ( 6.1)     0.914     
##   bin_aki48h (mean (SD))         0.17 (0.38)     0.081     
##   val_proctime (mean (SD))     369.49 (76.10)   <0.001     
##   val_crystalloid (mean (SD)) 6809.72 (2045.89)  0.138     
##   cat_rbc (%)                                    0.001     
##      >1                            51 (11.9)               
##      0                            331 (77.5)               
##      1                             45 (10.5)               
##   val_cpbtime (mean (SD))      111.30 (40.62)   <0.001     
##   val_ef (mean (SD))            53.66 (10.55)    0.282     
##   bin_ef40 = >40% (%)             375 (87.8)     0.259

Time with MAP < 65

## 33.33333% 66.66667% 
##        37        59
##                              Stratified by tertile
##                               t1                t2               
##   n                               434               427          
##   val_age (mean (SD))           65.20 (8.51)      67.31 (8.34)   
##   cat_gender = Male (%)           334 (77.0)        343 (80.3)   
##   val_bmi (mean (SD))           30.78 (5.95)      29.48 (5.66)   
##   val_egfr (mean (SD))          77.89 (20.38)     77.53 (19.24)  
##   bin_htn = 1 (%)                 119 (27.4)         96 (22.5)   
##   bin_diabetes = 1 (%)             87 (20.0)         79 (18.5)   
##   bin_mi = 1 (%)                   93 (21.4)        106 (24.8)   
##   bin_chf = 1 (%)                  14 ( 3.2)         10 ( 2.3)   
##   cat_ef (%)                                                     
##      15-20%                         1 ( 0.2)          0 ( 0.0)   
##      20-25%                         6 ( 1.4)          6 ( 1.4)   
##      25-30%                         7 ( 1.6)         13 ( 3.0)   
##      30-35%                        10 ( 2.3)          8 ( 1.9)   
##      35-40%                        17 ( 3.9)         15 ( 3.5)   
##      40-45%                        16 ( 3.7)         31 ( 7.3)   
##      45-50%                        32 ( 7.4)         33 ( 7.7)   
##      50-55%                        54 (12.4)         46 (10.8)   
##      55-60%                       197 (45.4)        194 (45.4)   
##      60-65%                        76 (17.5)         52 (12.2)   
##      65-70%                        15 ( 3.5)         23 ( 5.4)   
##      70-75%                         3 ( 0.7)          6 ( 1.4)   
##   bin_iabp = 1 (%)                  6 ( 1.4)          6 ( 1.4)   
##   bin_stroke = 1 (%)                7 ( 1.6)         12 ( 2.8)   
##   bin_pvd = 1 (%)                  11 ( 2.5)         12 ( 2.8)   
##   bin_cld = 1 (%)                  10 ( 2.3)          7 ( 1.6)   
##   bin_betablocker = 1 (%)         340 (78.3)        342 (80.1)   
##   bin_acearb = 1 (%)              289 (66.6)        287 (67.2)   
##   bin_statin = 1 (%)              366 (84.3)        359 (84.1)   
##   val_creatlst (mean (SD))       1.06 (0.38)       1.05 (0.34)   
##   bin_redo = 1 (%)                  0 ( 0.0)          0 ( 0.0)   
##   bin_emergent = 1 (%)             27 ( 6.2)         31 ( 7.3)   
##   bin_aki48h (mean (SD))         0.11 (0.31)       0.13 (0.34)   
##   val_proctime (mean (SD))     332.90 (63.86)    340.58 (60.28)  
##   val_crystalloid (mean (SD)) 6762.67 (2045.42) 6599.53 (2058.57)
##   cat_rbc (%)                                                    
##      >1                            20 ( 4.6)         23 ( 5.4)   
##      0                            384 (88.5)        368 (86.2)   
##      1                             30 ( 6.9)         36 ( 8.4)   
##   val_cpbtime (mean (SD))       94.94 (30.16)    100.19 (33.69)  
##   val_ef (mean (SD))            54.82 (9.68)      54.21 (10.08)  
##   bin_ef40 = >40% (%)             393 (90.6)        385 (90.2)   
##                              Stratified by tertile
##                               t3                p      test
##   n                               421                      
##   val_age (mean (SD))           68.35 (8.24)    <0.001     
##   cat_gender = Male (%)           333 (79.1)     0.473     
##   val_bmi (mean (SD))           29.90 (5.79)     0.004     
##   val_egfr (mean (SD))          72.91 (21.76)   <0.001     
##   bin_htn = 1 (%)                 116 (27.6)     0.155     
##   bin_diabetes = 1 (%)             88 (20.9)     0.673     
##   bin_mi = 1 (%)                  112 (26.6)     0.199     
##   bin_chf = 1 (%)                  13 ( 3.1)     0.708     
##   cat_ef (%)                                     0.007     
##      15-20%                         6 ( 1.4)               
##      20-25%                         2 ( 0.5)               
##      25-30%                        12 ( 2.9)               
##      30-35%                        18 ( 4.3)               
##      35-40%                        25 ( 5.9)               
##      40-45%                        32 ( 7.6)               
##      45-50%                        37 ( 8.8)               
##      50-55%                        46 (10.9)               
##      55-60%                       166 (39.4)               
##      60-65%                        59 (14.0)               
##      65-70%                        17 ( 4.0)               
##      70-75%                         1 ( 0.2)               
##   bin_iabp = 1 (%)                 17 ( 4.0)     0.011     
##   bin_stroke = 1 (%)                8 ( 1.9)     0.444     
##   bin_pvd = 1 (%)                  13 ( 3.1)     0.887     
##   bin_cld = 1 (%)                   9 ( 2.1)     0.772     
##   bin_betablocker = 1 (%)         341 (81.0)     0.616     
##   bin_acearb = 1 (%)              288 (68.4)     0.847     
##   bin_statin = 1 (%)              377 (89.5)     0.035     
##   val_creatlst (mean (SD))       1.14 (0.48)     0.003     
##   bin_redo = 1 (%)                  2 ( 0.5)     0.129     
##   bin_emergent = 1 (%)             25 ( 5.9)     0.711     
##   bin_aki48h (mean (SD))         0.19 (0.40)     0.001     
##   val_proctime (mean (SD))     374.38 (75.85)   <0.001     
##   val_crystalloid (mean (SD)) 6891.33 (2147.45)  0.124     
##   cat_rbc (%)                                   <0.001     
##      >1                            62 (14.7)               
##      0                            318 (75.5)               
##      1                             41 ( 9.7)               
##   val_cpbtime (mean (SD))      118.40 (41.27)   <0.001     
##   val_ef (mean (SD))            52.57 (10.98)    0.004     
##   bin_ef40 = >40% (%)             358 (85.0)     0.019

Time with MAP < 65 and CI < 2

## 33.33333% 66.66667% 
##         0         2
##                              Stratified by tertile
##                               t1                t2               
##   n                               692               187          
##   val_age (mean (SD))           65.13 (8.15)      66.94 (8.30)   
##   cat_gender = Male (%)           562 (81.2)        153 (81.8)   
##   val_bmi (mean (SD))           30.27 (5.79)      29.84 (6.13)   
##   val_egfr (mean (SD))          78.71 (20.70)     75.47 (20.03)  
##   bin_htn = 1 (%)                 162 (23.4)         61 (32.6)   
##   bin_diabetes = 1 (%)            122 (17.6)         43 (23.0)   
##   bin_mi = 1 (%)                  173 (25.0)         42 (22.5)   
##   bin_chf = 1 (%)                  13 ( 1.9)          3 ( 1.6)   
##   cat_ef (%)                                                     
##      15-20%                         3 ( 0.4)          2 ( 1.1)   
##      20-25%                         9 ( 1.3)          2 ( 1.1)   
##      25-30%                        15 ( 2.2)          5 ( 2.7)   
##      30-35%                        22 ( 3.2)          2 ( 1.1)   
##      35-40%                        27 ( 3.9)         11 ( 5.9)   
##      40-45%                        36 ( 5.2)         14 ( 7.5)   
##      45-50%                        55 ( 7.9)         17 ( 9.1)   
##      50-55%                        68 ( 9.8)         24 (12.8)   
##      55-60%                       319 (46.1)         81 (43.3)   
##      60-65%                        98 (14.2)         22 (11.8)   
##      65-70%                        33 ( 4.8)          7 ( 3.7)   
##      70-75%                         7 ( 1.0)          0 ( 0.0)   
##   bin_iabp = 1 (%)                 10 ( 1.4)          2 ( 1.1)   
##   bin_stroke = 1 (%)                9 ( 1.3)          5 ( 2.7)   
##   bin_pvd = 1 (%)                  18 ( 2.6)          5 ( 2.7)   
##   bin_cld = 1 (%)                  15 ( 2.2)          2 ( 1.1)   
##   bin_betablocker = 1 (%)         545 (78.8)        147 (78.6)   
##   bin_acearb = 1 (%)              467 (67.5)        114 (61.0)   
##   bin_statin = 1 (%)              596 (86.1)        160 (85.6)   
##   val_creatlst (mean (SD))       1.07 (0.42)       1.09 (0.39)   
##   bin_redo = 1 (%)                  0 ( 0.0)          0 ( 0.0)   
##   bin_emergent = 1 (%)             43 ( 6.2)         15 ( 8.0)   
##   bin_aki48h (mean (SD))         0.13 (0.34)       0.11 (0.31)   
##   val_proctime (mean (SD))     341.70 (63.48)    351.13 (71.10)  
##   val_crystalloid (mean (SD)) 6710.26 (2085.99) 6553.48 (2129.66)
##   cat_rbc (%)                                                    
##      >1                            40 ( 5.8)         11 ( 5.9)   
##      0                            599 (86.6)        163 (87.2)   
##      1                             53 ( 7.7)         13 ( 7.0)   
##   val_cpbtime (mean (SD))      101.89 (34.77)    103.00 (35.50)  
##   val_ef (mean (SD))            54.22 (10.30)     53.07 (10.05)  
##   bin_ef40 = >40% (%)             616 (89.0)        165 (88.2)   
##                              Stratified by tertile
##                               t3                p      test
##   n                               403                      
##   val_age (mean (SD))           70.04 (8.18)    <0.001     
##   cat_gender = Male (%)           295 (73.2)     0.004     
##   val_bmi (mean (SD))           29.79 (5.74)     0.358     
##   val_egfr (mean (SD))          72.02 (20.00)   <0.001     
##   bin_htn = 1 (%)                 108 (26.8)     0.033     
##   bin_diabetes = 1 (%)             89 (22.1)     0.101     
##   bin_mi = 1 (%)                   96 (23.8)     0.749     
##   bin_chf = 1 (%)                  21 ( 5.2)     0.003     
##   cat_ef (%)                                     0.566     
##      15-20%                         2 ( 0.5)               
##      20-25%                         3 ( 0.7)               
##      25-30%                        12 ( 3.0)               
##      30-35%                        12 ( 3.0)               
##      35-40%                        19 ( 4.7)               
##      40-45%                        29 ( 7.2)               
##      45-50%                        30 ( 7.4)               
##      50-55%                        54 (13.4)               
##      55-60%                       157 (39.0)               
##      60-65%                        67 (16.6)               
##      65-70%                        15 ( 3.7)               
##      70-75%                         3 ( 0.7)               
##   bin_iabp = 1 (%)                 17 ( 4.2)     0.006     
##   bin_stroke = 1 (%)               13 ( 3.2)     0.085     
##   bin_pvd = 1 (%)                  13 ( 3.2)     0.828     
##   bin_cld = 1 (%)                   9 ( 2.2)     0.601     
##   bin_betablocker = 1 (%)         331 (82.1)     0.369     
##   bin_acearb = 1 (%)              283 (70.2)     0.082     
##   bin_statin = 1 (%)              346 (85.9)     0.978     
##   val_creatlst (mean (SD))       1.10 (0.37)     0.441     
##   bin_redo = 1 (%)                  2 ( 0.5)     0.113     
##   bin_emergent = 1 (%)             25 ( 6.2)     0.649     
##   bin_aki48h (mean (SD))         0.18 (0.39)     0.026     
##   val_proctime (mean (SD))     360.81 (76.05)   <0.001     
##   val_crystalloid (mean (SD)) 6911.29 (2058.01)  0.115     
##   cat_rbc (%)                                   <0.001     
##      >1                            54 (13.4)               
##      0                            308 (76.4)               
##      1                             41 (10.2)               
##   val_cpbtime (mean (SD))      109.39 (39.84)    0.004     
##   val_ef (mean (SD))            53.68 (10.37)    0.360     
##   bin_ef40 = >40% (%)             355 (88.1)     0.883

Individuals with time in range

CI

MAP

MAP and CI

Table

MAP CI Mean (SD) n (%)
<65 <=2 4.9 (9.3) 381 (30)
<65 (2,2.4] 4.5 (7.2) 422 (33)
<65 (2.4, 2.8] 3.6 (6.5) 339 (26)
<65 >2.8 4.1 (8.3) 331 (26)
>=65 <=2 33 (38) 893 (70)
>=65 (2,2.4] 35 (28) 1118 (87)
>=65 (2.4, 2.8] 29 (24) 1087 (85)
>=65 >2.8 31 (37) 897 (70)

Figures

CI Exposure

Concurrent MAP/CI

Distribution of times in ranges

Regressions: primary analysis

Univariate regressions

Adjusted regressions

Controlling for:

  • Age
  • Sex
  • Bypass time
  • Baseline creatinine
  • BMI
  • Hypertension
  • Diabetes
  • MI
  • CHF
  • EF (continuous)
  • Beta blocker
  • Ace/Arb
  • Statin
  • Redo
  • Emergent
  • PVD
  • Chronic lung disease
  • Stroke
Observations 1275 (7 missing obs. deleted)
Dependent variable bin_aki48h
Type Generalized linear model
Family binomial
Link logit
𝛘²(25) 101.10
p 0.00
Pseudo-R² (Cragg-Uhler) 0.14
Pseudo-R² (McFadden) 0.10
AIC 1003.33
BIC 1137.24
exp(Est.) 2.5% 97.5% z val. p
(Intercept) 0.00 0.00 0.04 -4.77 0.00
hypo_q1 1.15 1.05 1.25 2.99 0.00
hypo_q2 0.96 0.85 1.08 -0.71 0.48
hypo_q3 1.03 0.89 1.19 0.40 0.69
hypo_q4 0.99 0.87 1.12 -0.19 0.85
normo_q1 0.98 0.95 1.01 -1.32 0.19
normo_q2 1.03 1.00 1.06 1.79 0.07
normo_q3 0.97 0.93 1.01 -1.48 0.14
normo_q4 1.01 0.98 1.04 0.78 0.44
cat_genderMale 1.03 0.67 1.56 0.11 0.91
val_creatlst 3.41 2.39 4.87 6.74 0.00
val_age 1.02 1.00 1.05 2.03 0.04
val_bmi 1.03 1.00 1.06 2.21 0.03
bin_htn 1.10 0.74 1.65 0.47 0.64
bin_diabetes 1.01 0.65 1.56 0.04 0.97
bin_stroke 1.00 0.35 2.87 0.00 1.00
val_ef 0.98 0.97 1.00 -1.86 0.06
bin_mi 1.29 0.88 1.88 1.31 0.19
bin_chf 0.72 0.26 1.96 -0.65 0.52
bin_pvd 0.64 0.21 1.90 -0.80 0.42
bin_cld 0.88 0.27 2.90 -0.21 0.84
bin_betablocker 1.00 0.62 1.62 0.01 0.99
bin_acearb 1.20 0.80 1.80 0.90 0.37
bin_statin 1.33 0.75 2.36 0.97 0.33
bin_redo 0.00 0.00 Inf -0.02 0.98
bin_emergent 0.99 0.50 1.97 -0.03 0.98
Standard errors: MLE

Nested models

Comparing MAP <65 model with all MAP,CI combos and MAP <65

## [1] 0.3986138
## [1] 0.3965954
## [1] 0.4136672
## [1] 0.4041968
Observations 1275 (7 missing obs. deleted)
Dependent variable bin_aki48h
Type Generalized linear model
Family binomial
Link logit
𝛘²(26) 103.47
p 0.00
Pseudo-R² (Cragg-Uhler) 0.14
Pseudo-R² (McFadden) 0.10
AIC 1002.96
BIC 1142.03
exp(Est.) 2.5% 97.5% z val. p
(Intercept) 0.00 0.00 0.03 -4.90 0.00
hypo_q1 1.10 1.00 1.22 1.89 0.06
hypo_q2 0.93 0.82 1.05 -1.18 0.24
hypo_q3 0.99 0.85 1.16 -0.07 0.94
hypo_q4 0.95 0.83 1.09 -0.77 0.44
normo_q1 0.98 0.95 1.01 -1.31 0.19
normo_q2 1.03 1.00 1.07 1.81 0.07
normo_q3 0.97 0.93 1.01 -1.43 0.15
normo_q4 1.01 0.98 1.04 0.79 0.43
map_65 1.03 0.99 1.07 1.57 0.12
cat_genderMale 0.99 0.65 1.52 -0.03 0.97
val_creatlst 3.43 2.39 4.90 6.73 0.00
val_age 1.02 1.00 1.05 2.08 0.04
val_bmi 1.03 1.00 1.06 2.15 0.03
bin_htn 1.10 0.74 1.65 0.48 0.63
bin_diabetes 1.01 0.65 1.57 0.06 0.95
bin_stroke 1.00 0.35 2.87 0.01 1.00
val_ef 0.99 0.97 1.00 -1.79 0.07
bin_mi 1.27 0.87 1.85 1.24 0.21
bin_chf 0.68 0.25 1.88 -0.74 0.46
bin_pvd 0.63 0.21 1.88 -0.83 0.41
bin_cld 0.89 0.27 2.93 -0.19 0.85
bin_betablocker 1.02 0.63 1.64 0.07 0.94
bin_acearb 1.22 0.81 1.82 0.95 0.34
bin_statin 1.29 0.73 2.29 0.86 0.39
bin_redo 0.00 0.00 Inf -0.02 0.98
bin_emergent 0.96 0.48 1.92 -0.10 0.92
Standard errors: MLE
## Analysis of Deviance Table
## 
## Model 1: bin_aki48h ~ map_65 + cat_gender + val_creatlst + val_age + val_bmi + 
##     bin_htn + bin_diabetes + bin_stroke + val_ef + bin_mi + bin_chf + 
##     bin_pvd + bin_cld + bin_betablocker + bin_acearb + bin_statin + 
##     bin_redo + bin_emergent
## Model 2: bin_aki48h ~ hypo_q1 + hypo_q2 + hypo_q3 + hypo_q4 + normo_q1 + 
##     normo_q2 + normo_q3 + normo_q4 + map_65 + cat_gender + val_creatlst + 
##     val_age + val_bmi + bin_htn + bin_diabetes + bin_stroke + 
##     val_ef + bin_mi + bin_chf + bin_pvd + bin_cld + bin_betablocker + 
##     bin_acearb + bin_statin + bin_redo + bin_emergent
##   Resid. Df Resid. Dev Df Deviance     F Pr(>F)
## 1      1256     959.30                         
## 2      1248     948.96  8   10.344 1.293 0.2417

Comparing MAP <65 model with low MAP low CI model

Observations 1275 (7 missing obs. deleted)
Dependent variable bin_aki48h
Type Generalized linear model
Family binomial
Link logit
𝛘²(19) 96.83
p 0.00
Pseudo-R² (Cragg-Uhler) 0.13
Pseudo-R² (McFadden) 0.09
AIC 995.60
BIC 1098.62
exp(Est.) 2.5% 97.5% z val. p
(Intercept) 0.00 0.00 0.04 -5.01 0.00
hypo_q1 1.09 1.00 1.18 1.92 0.05
map_65 1.02 0.99 1.05 1.34 0.18
cat_genderMale 1.01 0.66 1.53 0.04 0.97
val_creatlst 3.40 2.39 4.85 6.77 0.00
val_age 1.02 1.00 1.04 1.79 0.07
val_bmi 1.03 1.01 1.06 2.33 0.02
bin_htn 1.12 0.75 1.68 0.56 0.57
bin_diabetes 0.98 0.63 1.52 -0.08 0.94
bin_stroke 1.03 0.36 2.90 0.05 0.96
val_ef 0.99 0.97 1.00 -1.83 0.07
bin_mi 1.29 0.89 1.88 1.34 0.18
bin_chf 0.65 0.24 1.76 -0.85 0.40
bin_pvd 0.60 0.20 1.77 -0.92 0.36
bin_cld 0.94 0.28 3.09 -0.11 0.92
bin_betablocker 1.01 0.62 1.62 0.02 0.98
bin_acearb 1.23 0.82 1.84 1.01 0.31
bin_statin 1.23 0.69 2.18 0.71 0.48
bin_redo 0.00 0.00 47313893965827297202248635100497784265504111395082261302051242360360631031757257791775479333973855280483545755975339673103944459152916272939752444559557672820015247814212556503142600143289648151283092696634757109261343901313538717319050053392942023470847754315450522258764628522620251361180008022286532608.00 -0.03 0.97
bin_emergent 0.97 0.49 1.93 -0.08 0.94
Standard errors: MLE
## Analysis of Deviance Table
## 
## Model 1: bin_aki48h ~ map_65 + cat_gender + val_creatlst + val_age + val_bmi + 
##     bin_htn + bin_diabetes + bin_stroke + val_ef + bin_mi + bin_chf + 
##     bin_pvd + bin_cld + bin_betablocker + bin_acearb + bin_statin + 
##     bin_redo + bin_emergent
## Model 2: bin_aki48h ~ hypo_q1 + map_65 + cat_gender + val_creatlst + val_age + 
##     val_bmi + bin_htn + bin_diabetes + bin_stroke + val_ef + 
##     bin_mi + bin_chf + bin_pvd + bin_cld + bin_betablocker + 
##     bin_acearb + bin_statin + bin_redo + bin_emergent
##   Resid. Df Resid. Dev Df Deviance      F  Pr(>F)  
## 1      1256      959.3                             
## 2      1255      955.6  1   3.6979 3.6979 0.05448 .
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

Substitution

Sub 5 minutes MAP < 65, CI in quartile 1 (<2) to 5 minutes MAP < 65, CI in quartile 2 (2-2.4)

## 
##   Simultaneous Tests for General Linear Hypotheses
## 
## Fit: glm(formula = bin_aki48h ~ ., family = binomial(), data = df %>% 
##     select(contains("q"), bin_aki48h, cat_gender, val_creatlst, 
##         val_age, val_bmi, bin_htn, bin_diabetes, bin_stroke, 
##         val_ef, bin_mi, bin_chf, bin_pvd, bin_cld, bin_betablocker, 
##         bin_acearb, bin_statin, bin_redo, bin_emergent) %>% mutate(across(c(contains("q"), 
##     contains("map")), ~.x/5)))
## 
## Linear Hypotheses:
##        Estimate Std. Error z value Pr(>|z|)  
## 1 == 0 -0.17914    0.08536  -2.099   0.0358 *
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
## (Adjusted p values reported -- single-step method)
## [1] 0.8359889
## [1] 0.7071973 0.9882354

Sub 5 minutes MAP < 65, CI < 2 to 5 minutes MAP < 65, CI >= 2

## 
##   Simultaneous Tests for General Linear Hypotheses
## 
## Fit: glm(formula = bin_aki48h ~ low_map_low_ci + low_map_hi_ci + hi_map_low_ci + 
##     hi_map_hi_ci + cat_gender + val_creatlst + val_age + val_bmi + 
##     bin_htn + bin_diabetes + bin_stroke + val_ef + bin_mi + bin_chf + 
##     bin_pvd + bin_cld + bin_betablocker + bin_acearb + bin_statin + 
##     bin_redo + bin_emergent, family = binomial(), data = df2 %>% 
##     mutate(across(contains("map"), ~.x/5)))
## 
## Linear Hypotheses:
##        Estimate Std. Error z value Pr(>|z|)  
## 1 == 0 -0.15226    0.06079  -2.505   0.0123 *
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
## (Adjusted p values reported -- single-step method)
## [1] 0.858765
## [1] 0.7623051 0.9674306

Sub 5 minutes MAP < 65, CI < 2 with 5 minutes MAP >= 65, CI < 2

## 
##   Simultaneous Tests for General Linear Hypotheses
## 
## Fit: glm(formula = bin_aki48h ~ ., family = binomial(), data = df %>% 
##     select(contains("q"), bin_aki48h, cat_gender, val_creatlst, 
##         val_age, val_bmi, bin_htn, bin_diabetes, bin_stroke, 
##         val_ef, bin_mi, bin_chf, bin_pvd, bin_cld, bin_betablocker, 
##         bin_acearb, bin_statin, bin_redo, bin_emergent) %>% mutate(across(c(contains("q"), 
##     contains("map")), ~.x/5)))
## 
## Linear Hypotheses:
##        Estimate Std. Error z value Pr(>|z|)   
## 1 == 0 -0.15557    0.05211  -2.985  0.00283 **
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
## (Adjusted p values reported -- single-step method)
## [1] 0.8559272

Regressions: subgroup analyses

Univariate

LVEF groups

Shock groups

eGFR groups

Surgery phase

Tertiles

Quintiles

Adjusted with all bricks in model

LVEF groups

Shock groups

eGFR groups

Forest plot

Surgery phase

Tertiles

Quintiles

Lasagna Plots